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Interferences of the autonomic nervous system with drug induced QT prolongation: A point to consider in non-clinical safety studies

Archive ouverte | Champeroux, Pascal | CCSD

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Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Archive ouverte | Le Guennec, Jean-Yves | CCSD

International audience. Safety pharmacology aims to predict rare side effects of new drugs. We explored whether rare pro-arrhythmic effects could be linked to the variability of the effects of these drugs on ion cur...

Reducing endothelial NOS activation and interstitial fluid pressure with n –3 PUFA offset tumor chemoresistance

Archive ouverte | Kornfeld, Sophie | CCSD

International audience. The aim of this study was to determine how n-3 polyunsaturated fatty acid (PUFAs) counteracted tumor chemoresistance by restoring a functional vascularization. Rats with chemically induced ma...

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