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Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

Archive ouverte | Varrault, Annie | CCSD

International audience. PLAGL1/ZAC1 undergoes parental genomic imprinting , is paternally expressed, and is a member of the imprinted gene network (IGN). It encodes a zinc finger transcription factor with anti-proli...

A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation

Archive ouverte | Al Adhami, Hala | CCSD

International audience. Genomic imprinting is an epigenetic mechanism that restrains the expression of~100 eutherian genes in a parent-of-origin-specific manner. The reason for this selective targeting of genes with...

Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes

Archive ouverte | Mangoni, Matteo E. | CCSD

The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm and rate under physiological conditions. Compared to working myocardial cells, pacemaker cells express a specific array of ionic channel...

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