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In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression

Archive ouverte | Bouschet, Tristan | CCSD

International audience. In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for corticaltherapy. It is unknown to which extent epigenetic mech...

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

Archive ouverte | Varrault, Annie | CCSD

International audience. PLAGL1/ZAC1 undergoes parental genomic imprinting , is paternally expressed, and is a member of the imprinted gene network (IGN). It encodes a zinc finger transcription factor with anti-proli...

A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation

Archive ouverte | Al Adhami, Hala | CCSD

International audience. Genomic imprinting is an epigenetic mechanism that restrains the expression of~100 eutherian genes in a parent-of-origin-specific manner. The reason for this selective targeting of genes with...

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