Antimicrobial capacity of the freshwater planarians against S-aureus is under the control of Timeless

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Tsoumtsa, Landry Laure | Torre, Cedric | Trouplin, Virginie | Coiffard, Benjamin | Gimenez, Gregory | Mege, Jean-Louis | Ghigo, Eric

Edité par CCSD ; Taylor & Francis -

International audience. Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the antimicrobial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.

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