Bevacizumab Pharmacokinetics Influence Overall and Progression-Free Survival in Metastatic Colorectal Cancer Patients

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Caulet, Morgane | Lecomte, Thierry | Bouché, Olivier | Rollin, Jérôme | Gouilleux-Gruart, Valérie | Azzopardi, Nicolas | Léger, Julie | Borg, Christophe | Douillard, Jean-Yves | Manfredi, Sylvain | Smith, Denis | Capitain, Olivier | Ferru, Aurélie | Moussata, Driffa | Terrebone, Eric | Paintaud, Gilles | Ternant, David

Edité par CCSD ; Springer Verlag -

International audience. Clinical response to bevacizumab varies between patients treated for metastatic colorectal cancer (mCRC). The aim of this study was to quantify individual factors affecting bevacizumab pharmacokinetic variability and assess the relationship between bevacizumab concentrations and clinical outcomes.

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