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Genetic and epigenetic regulation of YKL-40 in childhood

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Guerra, Stefano | Melen, Erik | Sunyer, Jordi | Xu, Cheng-Jian | Lavi, Iris | Benet, Marta | Bustamante, Mariona | Carsin, Anne-Elie | Dobaño, Carlota | Guxens, Mònica | Tischer, Christina | Vrijheid, Martine | Kull, Inger | Bergström, Anna | Kumar, Ashish | Söderhäll, Cilla | Gehring, Ulrike | Dijkstra, Dorieke | van Der Vlies, Pieter | Wickman, Magnus | Bousquet, Jean | Postma, Dirkje, S. | Antó, Josep, M. | Koppelman, Gerard, H.

Edité par CCSD ; Elsevier -

International audience. Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several diseases, including asthma. Epigenetic regulation of circulating YKL-40 early in life is unknown.

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