Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
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Bernatsky, Sasha | García, Héctor a Velásquez | Spinelli, John J | Gaffney, Patrick | Smedby, Karin E | Ramsey-Goldman, Rosalind | Wang, Sophia S | Adami, Hans-Olov | Albanes, Demetrius | Angelucci, Emanuele | Ansell, Stephen M | Asmann, Yan W | Becker, Nikolaus | Benavente, Yolanda | Berndt, Sonja I | Bertrand, Kimberly A | Birmann, Brenda M | Boeing, Heiner | Boffetta, Paolo | Bracci, Paige M | Brennan, Paul | Brooks-Wilson, Angela R | Cerhan, James R | Chanock, Stephen J | Clavel, Jacqueline | Conde, Lucia | Cotenbader, Karen H | Cox, David G | Cozen, Wendy | Crouch, Simon | Roos, Anneclaire J De | Sanjose, Silvia De | Lollo, Simonetta Di | Diver, W Ryan | Dogan, Ahmet | Foretova, Lenka | Ghesquières, Hervé | Giles, Graham G | Glimelius, Bengt | Habermann, Thomas M | Haioun, Corinne | Hartge, Patricia | Hjalgrim, Henrik | Holford, Theodore R | Holly, Elizabeth A | Jackson, Rebecca D | Kaaks, Rudolph | Kane, Eleanor | Kelly, Rachel S | Klein, Robert J | Kraft, Peter | Kricker, Anne | Lan, Qing | Lawrence, Charles | Liebow, Mark | Lightfoot, Tracy | Link, Brian K | Maynadie, Marc | Mckay, James | Melbye, Mads | Molina, Thierry J | Monnereau, Alain | Morton, Lindsay M | Nieters, Alexandra | North, Kari E | Novak, Anne J | Offit, Kenneth | Purdue, Mark P | Rais, Marco | Riby, Jacques | Roman, Eve | Rothman, Nathaniel | Salles, Gilles | Severi, Gianluca | Severson, Richard K | Skibola, Christine F | Slager, Susan L | Smith, Alex | Smith, Martyn T | Southey, Melissa C | Staines, Anthony | Teras, Lauren R | Thompson, Carrie A | Tilly, Hervé | Tinker, Lesley F | Tjonneland, Anne | Turner, Jenny | Vajdic, Claire M | Vermeulen, Roel C H | Vijai, Joseph | Vineis, Paolo | Virtamo, Jarmo | Wang, Zhaoming | Weinstein, Stephanie | Witzig, Thomas E | Zelenetz, Andrew | Zeleniuch-Jacquotte, Anne | Zhang, Yawei | Zheng, Tongzhang | And, Mariagrazia Zucca | Clarke, Ann E
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CCSD ; BMJ -
International audience.
ObjectiveDeterminants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.ResultsAmong the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.ConclusionsThese data suggest several plausible genetic links between DLBCL and SLE.
