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UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

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Militti, Cristina | Maenner, Sylvain | Becker, Peter | Gebauer, Fátima

Edité par CCSD ; Nature Publishing Group -

International audience. Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.

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