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Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response

Archive ouverte | Cerles, Olivier | CCSD

International audience. Neuropathic pain is a limiting factor of platinum-based che-motherapies. We sought to investigate the neuroprotective potential of niclosamide in peripheral neuropathies induced by oxali-plat...

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Archive ouverte | Cerles, Olivier | CCSD

International audience. The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are...

Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding

Archive ouverte | Kavian, Niloufar | CCSD

International audience. OBJECTIVE:Endothelial cell (EC) damage in systemic sclerosis (SSc) is reflected by the shedding of microparticles (MPs). The aim of this study was to show that inhibiting MP release using pan...

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