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Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation

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Wood, Kathleen | Gallat, François-Xavier | Otten, Renee | van Heel, Auke J | Lethier, Mathilde | van Eijck, Lambert | Moulin, Martin | Haertlein, Michael | Weik, Martin | Mulder, Frans a A | Van heel, Auke J. | Van eijck, Lambert | Mulder, Frans A. A.

Edité par CCSD ; Wiley-VCH Verlag -

International audience. By specifically labeling leucine/valine methyl groups and lysine side chains "inside" and "outside" dynamics of proteins on the nanosecond timescale are compared using neutron scattering. Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition.

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