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An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes

Archive ouverte | Aigle, B. | CCSD

International audience. Streptomyces ambofaciens RP181110 produces the macrolide polyketide spiramycin. Like many other Streptomyces species, the RP181110 strain is prone to genetic instability involving genomic rea...

Stimulation of Genetic Instability and Associated Large Genomic Rearrangements in Streptomyces ambofaciens by Three Fluoroquinolones

Archive ouverte | Volff, Jean-Nicolas | CCSD

International audience. In Streptomyces ambofaciens NSA2002, pigmented wild-type colonies spontaneously give rise to pigment-negative (Pig-) mutants at a frequency of about 0.5%. This genetic instability is related ...

Analysis of genome instability in Streptomyces ambofaciens

Archive ouverte | Schneider, Dominique | CCSD

International audience. Genetic instability in Streptomyces ambofaciens DSM 40697 is correlated with genomic instability characterized by multiple rearrangements (deletions and/or amplifications) occurring in a larg...

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