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MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

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Beyrouthy, Racha | Robin, Frédéric | Lessene, Aude | Lacombat, Igor | Dortet, Laurent | Naas, Thierry | Ponties, Valérie | Bonnet, Richard

Edité par CCSD ; American Society for Microbiology -

International audience. The spread of mcr-1-encoding plasmids into carbapenem-resistant En-terobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

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