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Transcriptional alterations in glioma result primarily from DNA methylation independent mechanisms

Archive ouverte | Court, Franck | CCSD

International audience. In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, incl...

The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

Archive ouverte | Xavier-Magalhães, Ana | CCSD

International audience. The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary br...

Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage

Archive ouverte | Le Boiteux, Elisa | CCSD

International audience

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