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Amino Acid Signaling in Saccharomyces cerevisiae: a Permease- Like Sensor of External Amino Acids and F-Box Protein Grr1p Are Required for Transcriptional Induction of the AGP1 Gene, Which Encodes a Broad-Specificity Amino Acid Permease

Archive ouverte | Iraqui, Ismaïl | CCSD

International audience. The SSY1 gene of Saccharomyces cerevisiae encodes a member of a large family of amino acid permeases. Compared to the 17 other proteins of this family, however, Ssy1p displays unusual structu...

Unraveling networks of co-regulated genes on the sole basis of genome sequences

Archive ouverte | Brohee, Sylvain | CCSD

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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

Archive ouverte | Srivastava, Prashant K | CCSD

International audience. The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally validated a general computational fr...

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