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Toxicokinetics of chlordecone in goats: Implications for risk management in French West Indies
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The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution ofsoils. CLD is known to be potentially transferred towards animal products of animals reared outdoors,mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailablewhen administered to farm animals. Currently there is a need to quantify the level of CLD absorption andits toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered asimportant farm species in the French West Indies. The objective of this study was to evaluate the absorptionrate and the half-life of CLD in the non-lactating goat. The goats were administered eitherintravenously (i.v., n ¼ 6) or orally (p.o., n ¼ 6) one dose (1 mg kg 1 body weight) of CLD. Blood sampleswere collected at defined times up to 160 days post-dosing. CLD was analyzed in serum by highresolutiongas chromatography. A comparison of the area under the serum concentration-time curves(AUC) showed that the i.v. route is equivalent to the oral route. Thus, CLD is considered almost completelyabsorbed after p.o. administration, as shown by the mean absolute bioavailability. The comparison betweenthe pharmacokinetic profiles of CLD following oral and intravenous dose showed a difference during the first 14 days and a similar kinetic after this period. The half-life of CLD in serum was close to 20 days. These results highlight a possible strategy of decontamination due to the short half-life of CLD, obtained in dry goats that did not excrete fat matter.
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