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Protein Status Modulates the Hedonic Value of Protein Meals in Rat

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Chaumontet, Catherine, C. | Recio, Isidra | Darcel, Nicolas | Fromentin, Gilles | Tomé, Daniel

Edité par CCSD ; Federation of American Society of Experimental Biology -

WOS:000361470505146. International audience. Protein is an indispensable component of the diet and a low protein status usually induces preferences fo rprotein-rich food in animal and in human. This study hypothesized that these preferences involve a modulation of the activity of the hedonic reward system. Methods: Male adult Wistar rats received ad-libitum for 15 days a normoprotein (NP) or a low-protein (P6) diet containing either 14% or 6% protein as energy, and were trained to receive a morning calibrated meal. The last day of the feeding period each group was separated in 3 subgroups, which received a morning calibrated P6, NP or high-protein (HP: 55% protein as energy) meal. The brain was removed 90 minutes after the meal and activation of the nucleus accumbens (NAcc), a brain area implicated in the reward system, was estimated by immunofluorescence staining of c-Fos protein. Results: Food intake was not different between groups but body weight gain was lower in P6 compared to NP-diet rats. In the NP-diet group, the HP and P6 meals both induced lower NAcc activation compared to the NP meal (NP>HP,P6). In the P6-diet group, postprandial NAcc activation correlated with the protein content of the meal (HP>NP>P6), and it was significantly higher compared to NP-diet rats after the HP and NP meals and remains low following P6 meal, respectively. Discussion: In a situation of protein deficiency the preferences for protein could be related to higher hedonic value of protein-containing meals. In contrast, protein sufficiency lowers the hedonic value of protein-containing meals.

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