Study of Dopamine Receptor and Dopamine Transporter Networks in Mice

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Gorgievski, Victor | Tzavara, Eleni T. | Giros, Bruno

Edité par CCSD ; HUMANA PRESS INC -

International audience. Dopamine (DA) dysregulation is a core feature in Parkinson's disease and in addictive disorders. DA has been also implicated in central nervous system affective and cognitive pathologies such as bipolar disorder, schizophrenia, and attention deficit and hyperactivity disorder (ADHD). The first studies of genetically engineered mice targeting components of the DA system focused on motor behavior and on the action of addictive drugs. However, in the course of the last 20 years (the first KO relevant to the DA system to be generated were those of the D1 receptors in 1994), we have seen an increasing shift in the use of these mutants: from tools to unravel the pharmacology of addiction integrated to in vivo models to study DA-related affective and cognitive disorders.

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