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Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression

Archive ouverte | Vassallo, Paula, Frizera | CCSD

International audience. Key Points • We demonstrate that PT promotes ECFCs dysfunction by inducing stress-induced premature senescence. • Our data reveal that SIRT1 deficiency drives PT-ECFC senescence, and acts as ...

Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6

Archive ouverte | Simoncini, Stephanie | CCSD

International audience. Senescent cells may exert detrimental effect on microenvironment through the secretion of soluble factors and the release of extracellular vesicles, such as microparticles, key actors in agei...

Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction

Archive ouverte | Grandvuillemin, Isabelle | CCSD

International audience. Individuals born after intrauterine growth restriction (IUGR) are at increased risk of developing cardiovascular diseases in adulthood, notably hypertension (HTN). Alterations in the vascular...

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