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Inside the complex regulation of Pseudomonas aeruginosa chaperone usher systems.

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Giraud, Caroline | Bentzmann, Sophie, De

Edité par CCSD ; Society for Applied Microbiology and Wiley-Blackwell -

International audience. Pseudomonas aeruginosa assembles several cell surface-associated organelles, including those of the chaperone usher (CU) pathway. Five different CU loci have been identified and characterized in various strains of P.aeruginosa. However, their potential functional redundancy, particularly in biofilm formation, is supported by the control of their expression by a complex and specific regulatory network. Here, we review recent findings relating to this network. The control exerted by this network involves transcriptional repressors and activators, a phase-variable mechanism, a second intracellular messenger (c-di-GMP) and chemosensory and two-component systems.

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