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Conformational footprinting of proteins using a combination of top- down electron transfer dissociation and ion mobility

Archive ouverte | Konijnenberg, Albert | CCSD

In recent years native mass spectrometry has been increasingly employed to study protein structure. As such a thorough understanding of the effect of the gas-phase on protein structure is becoming increasingly important. We show h...

A community effort in SARS‐CoV‐2 drug discovery

Archive ouverte | Schimunek, Johannes | CCSD

International audience. The COVID‐19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small‐molec...

Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment

Archive ouverte | Konijnenberg, Albert | CCSD

International audience. Here we study the intact stoichiometry and top-down fragmentation behavior of three integral membrane proteins which were natively reconstituted into detergent micelles: the mechano-sensitive...

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