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A mutation map for human glycoside hydrolase genes

Archive ouverte | Hansen, Lars | CCSD

International audience. Glycoside hydrolases (GHs) are found in all domains of life, and at least 87 distinct genes encoding proteins related to GHs are found in the human genome. GHs serve diverse functions from di...

Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases

Archive ouverte | Joshi, Hiren | CCSD

International audience. Glycosylation of proteins, lipids and proteoglycans in human cells involves at least 167 identified glycosyltransferases (GTfs), and these orchestrate the biosynthesis of diverse types of gly...

Display of the human mucinome with defined O-glycans by gene engineered cells

Archive ouverte | Nason, Rebecca | CCSD

International audience. Abstract Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces and constitute the major macromolecules in most body fluids. Mucins are primarily defined...

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