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Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Archive ouverte | Zakraoui, Ons | CCSD

International audience. Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we...

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Archive ouverte | Tarhouni-Jabberi, Safa | CCSD

International audience. Conventional treatment of advanced colorectal cancer is associated with tumor resistance and toxicity towards normal tissues. Therefore, development of effective anticancer therapeutic altern...

Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells

Archive ouverte | Hammouda, Manel B. | CCSD

International audience. Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties. Despite the recent promising news from t...

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