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Cooperativity, specificity, and evolutionary stability of polycomb targeting in Drosophila

Archive ouverte | Schuettengruber, B. | CCSD

International audience. Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-...

The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression.

Archive ouverte | Grienenberger, A. | CCSD

Transient loss of Polycomb components induces an epigenetic cancer fate

Archive ouverte | Parreno, Victoria | CCSD

Cell fate depends on genetic, epigenetic and environmental inputs that are interconnected, making it difficult to disentangle their respective contributions to cell fate decisions 1-3 , and epigenetic reprogramming is a major cont...

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