Growth hormone level at admission and its evolution during refeeding are predictive of short-term outcome in restrictive anorexia nervosa

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Nogueira, Jp | Valéro, René | Maraninchi, Marie | Lorec, Anne, Marie | Samuelian-Massat, Catherine | Bégu-Le Corroller, Audrey | Nicolay, Alain | Gaudart, Jean | Portugal, Henri | Vialettes, Bernard

Edité par CCSD ; Cambridge University Press (CUP) -

International audience. The growth hormone (GH)– insulin-like growth factor-1 (IGF-1) axis is dramatically altered in patients with anorexia nervosa (AN). The aim of the present study was to investigate whether GH and IGF-1 could be predictors of outcome in patients with a restrictive form of AN. Blood levels of GH, IGF-1, adipocytokines, ghrelin, insulin, glucose, and sex and thyroid hormones were measured in eleven women inpa-tients with AN and in ten healthy women controls. Three stages were compared during refeeding: admission (T0), when BMI reached 16 kg/m 2 (T1) and at discharge when BMI reached 17·5 kg/m 2 (T2). Clinical status was assessed 6 months after discharge from hospital (T3), and remission was defined by the maintenance of a BMI $ 17·5 kg/m

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