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Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B

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Morizot, Gloria | Jouffroy, Romain | Faye, Albert | Chabert, Paul | Belhouari, Katia | Calin, Ruxandra | Charlier, Caroline | Miailhes, Patrick | Siriez, Jean-Yves | Mouri, Oussama | Yera, Hélène | Gilquin, Jacques | Tubiana, Roland | Lanternier, Fanny | Mamzer, Marie-France | Legendre, Christophe | Peyramond, Dominique | Caumes, Eric | Lortholary, Olivier | Buffet, Pierre

Edité par CCSD ; Public Library of Science -

International audience. We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.

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