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GATA-4 transcription factor regulates hepatic hepcidin expression.

Archive ouverte | Island, Marie-Laure | CCSD

International audience. Hepcidin, an hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regula...

Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form.

Archive ouverte | Fatih, Nadia | CCSD

International audience. During the inflammatory process, hepcidin overexpression favours the development of anaemia of chronic diseases which represents the second most common form of anaemia worldwide. The identifi...

Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice

Archive ouverte | Cavey, Thibault | CCSD

International audience. Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator, that favors the iron sequestration in the spleen. Genetic iron overload related to hepcidin i...

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