Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

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Conde, L. | Halperin, E. | Akers, N. K. | Brown, K. M. | Smedby, K. E. | Rothman, N. | Nieters, A. | Slager, S. L. | Brooks-Wilson, A. | Agana, L. | Riby, J. | Liu, J. | Adami, H. O. | Darabi, H. | Hjalgrim, H. | Low, H. Q. | Humphreys, K. | Melbye, M. | Chang, E. T. | Glimelius, B. | Cozen, W. | Davis, S. | Hartge, P. | Morton, L. M. | Schenk, M. | Wang, S. S. | Armstrong, B. | Kricker, A. | Milliken, S. | Purdue, M. P. | Vajdic, C. M. | Boyle, P. | Lan, Q. | Zahm, S. H. | Zhang, Y. | Zheng, T. | Becker, N. | Benavente, Y. | Boffetta, P. | Brennan, P. | Butterbach, K. | Cocco, P. | Foretova, L. | Maynadie, M. | Sanjose, S., De | Staines, A. | Spinelli, J. J. | Achenbach, S. J. | Call, T. G. | Camp, N. J. | Glenn, M. | Caporaso, N. E. | Cerhan, J. R. | Cunningham, J. M. | Goldin, L. R. | Hanson, C. A. | Kay, N. E. | Lanasa, M. C. | Leis, J. F. | Marti, G. E. | Rabe, K. G. | Rassenti, L. Z. | Spector, L. G. | Strom, S. S. | Vachon, C. M. | Weinberg, J. B. | Holly, E. A. | Chanock, S. | Smith, M. T. | Bracci, P. M. | Skibola, C. F.

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Conde, Lucia Halperin, Eran Akers, Nicholas K Brown, Kevin M Smedby, Karin E Rothman, Nathaniel Nieters, Alexandra Slager, Susan L Brooks-Wilson, Angela Agana, Luz Riby, Jacques Liu, Jianjun Adami, Hans-Olov Darabi, Hatef Hjalgrim, Henrik Low, Hui-Qi Humphreys, Keith Melbye, Mads Chang, Ellen T Glimelius, Bengt Cozen, Wendy Davis, Scott Hartge, Patricia Morton, Lindsay M Schenk, Maryjean Wang, Sophia S Armstrong, Bruce Kricker, Anne Milliken, Sam Purdue, Mark P Vajdic, Claire M Boyle, Peter Lan, Qing Zahm, Shelia H Zhang, Yawei Zheng, Tongzhang Becker, Nikolaus Benavente, Yolanda Boffetta, Paolo Brennan, Paul Butterbach, Katja Cocco, Pierluigi Foretova, Lenka Maynadie, Marc de Sanjose, Silvia Staines, Anthony Spinelli, John J Achenbach, Sara J Call, Timothy G Camp, Nicola J Glenn, Martha Caporaso, Neil E Cerhan, James R Cunningham, Julie M Goldin, Lynn R Hanson, Curtis A Kay, Neil E Lanasa, Mark C Leis, Jose F Marti, Gerald E Rabe, Kari G Rassenti, Laura Z Spector, Logan G Strom, Sara S Vachon, Celine M Weinberg, J Brice Holly, Elizabeth A Chanock, Stephen Smith, Martyn T Bracci, Paige M Skibola, Christine F eng CA104682/CA/NCI NIH HHS/ CA122663/CA/NCI NIH HHS/ CA45614/CA/NCI NIH HHS/ CA89745/CA/NCI NIH HHS/ R01 CA087014-01A1/CA/NCI NIH HHS/ R01 CA092153-09/CA/NCI NIH HHS/ R03 CA089745-01/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2010/07/20 06:00 Nat Genet. 2010 Aug;42(8):661-4. doi: 10.1038/ng.626. Epub 2010 Jul 18.. International audience. To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

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