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Selective bile canalicular changes induced by cholestatic drugs

Archive ouverte | Burbank, M. | CCSD

International audience. Many drugs have been reported to induce cholestasis in a dose-dependent or independent (idiosyncratic) manner. Intrahepatic cholestasis represents around 40% of drug-induced injuries and up t...

A dynamic mathematical model of bile acid clearance in HepaRG cells

Archive ouverte | Kaschek, D. | CCSD

International audience. A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid (TCA) in human HepaRG cells is presented. The highly rep...

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Archive ouverte | Guillouzo, A. | CCSD

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