Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation

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Marchand, T. | Lamy, T. | Finel, H. | Arcese, W. | Choquet, S. | Finke, J. | Huynh, A. | Irrera, G. | Karakasis, D. | Konopacki, J. | Lambert, J. | Michieli, M. | Schouten, H. C. | Schroyens, W. | Sucak, G. | Tischer, J. | Vandenberghe, E. | Dreger, P

Edité par CCSD ; Springer Nature -

International audience. Letter to the Editor. Large granular lymphocyte (LGL) leukemia is a rare lymphoproliferative disorder characterized by clonal expansion of either CD3+ cytotoxic T-lymphocytes or CD3− NK cells.1 WHO (World Health Organization) classification has recognized LGL leukemia as a specific entity among the subgroup of mature peripheral T-cell neoplasms. Clinical presentation is dominated by splenomegaly, neutropenia with recurrent infections and autoimmune manifestations. Due to low incidence and thus the lack of prospective studies, no standard treatment has been established in LGL leukemia.

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