Meiotic crossover patterns: obligatory crossover, interference and homeostasis in a single process.

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Wang, Shunxin | Zickler, Denise | Kleckner, Nancy | Zhang, Liangran

Edité par CCSD ; Taylor & Francis -

International audience. During meiosis, crossover recombination is tightly regulated. A spatial patterning phenomenon known as interference ensures that crossovers are well-spaced along the chromosomes. Additionally, every pair of homologs acquires at least one crossover. A third feature, crossover homeostasis, buffers the system such that the number of crossovers remains steady despite decreases or increases in the number of earlier recombinational interactions. Here we summarize recent work from our laboratory supporting the idea that all 3 of these aspects are intrinsic consequences of a single basic process and suggesting that the underlying logic of this process corresponds to that embodied in a particular (beam-film) model.

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