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Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Archive ouverte | Lopez-Rios, Javier | CCSD

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access. The large spectrum of limb morphologies reflects the wide evolutionary diversific...

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Archive ouverte | Malkmus, Jonas | CCSD

International audience. Abstract Precise cis -regulatory control of gene expression is essential for normal embryogenesis and tissue development. The BMP antagonist Gremlin1 ( Grem1 ) is a key node in the signalling...

Conserved Cis -Acting Range Extender Element Mediates Extreme Long-Range Enhancer Activity in Mammals

Archive ouverte | Bower, Grace | CCSD

Abstract While most mammalian enhancers regulate their cognate promoters over moderate distances of tens of kilobases (kb), some enhancers act over distances in the megabase range. The sequence features enabling such extreme-dista...

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