CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells.

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Amé-Thomas, Patricia | Hoeller, Sylvia | Artchounin, Catherine | Misiak, Jan | Braza, Mounia Sabrina | Jean, Rachel | Le Priol, Jérôme | Monvoisin, Céline | Martin, Nadine | Gaulard, Philippe | Tarte, Karin

Edité par CCSD ; American Society of Hematology -

International audience. In follicular lymphoma (FL), follicular helper T cells (TFH) have been depicted as one of the main components of the malignant B-cell niche and a promising therapeutic target. Although defined by their capacity to sustain FL B-cell growth together with specific gene expression and cytokine secretion profiles, FL-TFH constitute a heterogeneous cell population. However, specific markers reflecting such functional heterogeneity are still lacking. In this study, we demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary lymphoid organs. Importantly, this subset is amplified in the FL context, unlike in other B-cell lymphomas with a follicular growth pattern. Furthermore, whereas FL-TFH produce high levels of interleukin (IL)-21 and low levels of IL-17 irrespectively of their CD10 expression, CD10pos FL-TFH specifically exhibit an IL-4hiIFN-γloTNF-αhi cytokine profile associated with a high capacity to sustain directly and indirectly malignant B-cell survival. Altogether, our results highlight the important role of this novel functional subset in the FL cell niche.

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