Nongenomic effects of cisplatin: acute inhibition of mechanosensitive transporters and channels without actin remodeling.

Archive ouverte | Milosavljevic, Nina | CCSD

International audience. Cisplatin is an antineoplastic drug, mostly documented to cause cell death through the formation of DNA adducts. In patients, it exhibits a range of short-term side effects that are unlikely ...

Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains.

Archive ouverte | Tekpli, Xavier | CCSD

International audience. The Na+/H+ exchanger 1, which plays an essential role in intracellular pH regulation in most tissues, is also known to be a key actor in both proliferative and apoptotic processes. Its activa...

L'échangeur Na+/H+ un intégrateur cellulaire contrôlé par le pH interne, les voies de signalisation et l'environnement membranaire

Archive ouverte | Poët, Mallorie | CCSD