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Exposure to chlorinated solvents and lung cancer: results of the ICARE study

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Mattei, Francesca | Guida, Florence | Matrat, Mireille | Cenée, Sylvie | Cyr, Diane | Sanchez, Marie | Radoi, Loredana | Menvielle, Gwenn | Jellouli, Fatima | Carton, Matthieu | Bara, Simona | Marrer, Emilie | Luce, Danièle | Stücker, Isabelle

Edité par CCSD ; BMJ Publishing Group -

International audience. OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.

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