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SHOC1 and PTD form an XPF-ERCC1-like complexthat is required for formation of class I crossovers

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Macaisne, Nicolas, N. | Vignard, Julien | Mercier, Raphaël, R.

Edité par CCSD ; Company of Biologists -

Two distinct pathways for meiotic crossover formation coexist in most eukaryotes. The Arabidopsis SHOC1 protein is required forclass I crossovers and shows sequence similarity with the XPF endonuclease family. Active XPF endonucleases form a heterodimerwith ERCC1 proteins. Here, we show that PTD, an ERCC1-like protein, is required for class-I-interfering crossovers along withSHOC1, MSH4, MSH5, MER3 and MLH3. SHOC1 interacts with PTD in a two-hybrid assay, through its XPF-like nuclease-(HhH)2domain. We propose that a XPF-ERCC1-like heterodimer, represented by SHOC1 and PTD in Arabidopsis, involving Zip2 inSaccharomyces cerevisiae and C9orf84 in human, is required for formation of class I crossovers.

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