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FOXL2 versus SOX9: a lifelong "battle of the sexes".

Archive ouverte | Veitia, Reiner A | CCSD

International audience. Testis determination in most mammals is regulated by a genetic hierarchy initiated by the SRY gene. Early ovarian development has long been thought of as a default pathway switched on passive...

A generalized model of gene dosage and dominant negative effects in macromolecular complexes.

Archive ouverte | Veitia, Reiner A | CCSD

International audience. Most genes and their corresponding products are supposed to be involved in genetic or biochemical interactions. A typical example is provided by macromolecular complexes, which may contain te...

Dominant negative factors in health and disease.

Archive ouverte | Veitia, Reiner A | CCSD

International audience. The idea of dominant mutations that interfere with the activity of a normal gene product has been known for more than 80 years-the famous Muller's antimorphs. However, only over half a centur...

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