Afficher la couverture 'The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism. | Vera-Otarola, Jorge' en grand format
/5

0 avis

The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Archive ouverte

Vera-Otarola, Jorge | Solis, Loretto | Soto-Rifo, Ricardo | Ricci, Emiliano P | Pino, Karla | Tischler, Nicole D | Ohlmann, Théophile | Darlix, Jean-Luc | López-Lastra, Marcelo

Edité par CCSD ; American Society for Microbiology -

International audience. The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

Consulter en ligne

Suggestions

Du même auteur

Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.

Archive ouverte | Charnay, Nicolas | CCSD

International audience. BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) Tat protein is a major viral transactivator required for HIV-1 replication. In the nucleus Tat greatly stimulates the synthesis of ...

miRNA repression of translation in vitro takes place during 43S ribosomal scanning.

Archive ouverte | Ricci, Emiliano P | CCSD

International audience. microRNAs (miRNAs) regulate gene expression at multiple levels by repressing translation, stimulating deadenylation and inducing the premature decay of target messenger RNAs (mRNAs). Although...

Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation.

Archive ouverte | Soto-Rifo, Ricardo | CCSD

International audience. The 5'-untranslated region (5'-UTR) of the genomic RNA of human immunodeficiency viruses type-1 (HIV-1) and type-2 (HIV-2) is composed of highly structured RNA motifs essential for viral repl...

Chargement des enrichissements...