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The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

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Maison, Christèle | Romeo, Kelly | Bailly, Delphine | Dubarry, Marion | Quivy, Jean-Pierre | Almouzni, Geneviève

Edité par CCSD ; Nature Publishing Group -

International audience. SUMOylation promotes targeting of HP1α to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1α accumulation at this location. SENP7 interacts directly with HP1α, localizes at HP1-enriched pericentric domains and can deconjugate SUMOylated HP1α in vivo. Depletion of SENP7 delocalizes HP1α from pericentric heterochromatin without affecting H3K9me3 levels. We propose that following targeting of HP1α, a subsequent deSUMOylation event enables HP1α retention at these domains.

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