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Analysis of exposure–response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology

Archive ouverte | Delattre, Maud | CCSD

International audience. We propose to describe exposure–response relationship of an antiepileptic agent, using mixed hidden Markov modeling methodology, to reveal additional insights in the mode of the drug action w...

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Archive ouverte | Delattre, Maud | CCSD

International audience

Maximum likelihood estimation in discrete mixed hidden Markov models using the SAEM algorithm

Archive ouverte | Delattre, Maud | CCSD

International audience. Mixed hidden Markov models have been recently defined in the literature as an extension of hidden Markov models for dealing with population studies. The notion of mixed hidden Markov models i...

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