UniPathway: a resource for the exploration and annotation of metabolic pathways.

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Morgat, Anne | Coissac, Eric | Coudert, Elisabeth | Axelsen, Kristian B | Keller, Guillaume | Bairoch, Amos | Bridge, Alan | Bougueleret, Lydie | Xenarios, Ioannis | Viari, Alain

Edité par CCSD ; Oxford University Press -

International audience. UniPathway (http://www.unipathway.org) is a fully manually curated resource for the representation and annotation of metabolic pathways. UniPathway provides explicit representations of enzyme-catalyzed and spontaneous chemical reactions, as well as a hierarchical representation of metabolic pathways. This hierarchy uses linear subpathways as the basic building block for the assembly of larger and more complex pathways, including species-specific pathway variants. All of the pathway data in UniPathway has been extensively cross-linked to existing pathway resources such as KEGG and MetaCyc, as well as sequence resources such as the UniProt KnowledgeBase (UniProtKB), for which UniPathway provides a controlled vocabulary for pathway annotation. We introduce here the basic concepts underlying the UniPathway resource, with the aim of allowing users to fully exploit the information provided by UniPathway.

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