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Intercellular carbon nanotube translocation assessed by flow cytometry imaging.

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Marangon, Iris | Boggetto, Nicole | Ménard-Moyon, Cécilia | Venturelli, Enrica | Béoutis, Marie-Lys | Péchoux, Christine | Luciani, Nathalie | Wilhelm, Claire | Bianco, Alberto | Gazeau, Florence

Edité par CCSD ; American Chemical Society -

International audience. The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.

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