Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss.

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de Saint Martin, Luc | Duchemin, Jérôme | Bohec, Caroline | Couturaud, Francis | Mottier, Dominique | Collet, Michel | Blouch, Marie-Thérèse | Pasquier, Elisabeth

Edité par CCSD ; Elsevier -

International audience. Compared with 537 parous controls with no history of pregnancy loss, a lower thrombomodulin-related inhibition of the endogenous thrombin potential was measured in 264 cases with previous unexplained pregnancy loss, especially when losses occurred between 9 and 12 weeks of gestation. Adjusting age, protein S, factor VIII, factor V Leiden, and prothrombin G20210A did not change the results.

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