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Impact of orlistat initiation on cardiovascular treatment use: a 6-year population-based cohort study

Archive ouverte | Czernichow, Sébastien | CCSD

International audience. Background: Trials of weight-loss drugs indicate some benefits on lipids, blood glucose, or blood pressure levels. Since obesity is associated with increased cardiovascular (CV) medication us...

Estimating measures of interaction on an additive scale for preventive exposures

Archive ouverte | Knol, Mirjam J. | CCSD

International audience. Measures of interaction on an additive scale (relative excess risk due to interaction [RERI], attributable proportion [AP], synergy index [S]), were developed for risk factors rather than pre...

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Archive ouverte | Schmidt, Amand F. | CCSD

International audience. BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart dis...

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