Carcinogen-induced lipid membrane remodelling is essential for the NHE-1 activation involved in related apoptosis

Archive ouverte | Tekpli, Xavier | CCSD

Importance of plasma membrane dynamics in chemical-induced carcinogenesis.

Archive ouverte | Tekpli, Xavier | CCSD

International audience. In the last decade, a lot of patents have been filled regarding molecular biology and functions of cellular membranes. The membrane bilayer model has evolved from a static, passive, homogeneo...

NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function.

Archive ouverte | Tekpli, Xavier | CCSD

International audience. BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are ubiquitous toxic environmental pollutants capable of inducing cell death. Intracellular pH plays a key...