Afficher la couverture 'In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes. | Dubar, Faustine' en grand format
/5

0 avis

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes.

Archive ouverte

Dubar, Faustine | Bohic, Sylvain | Slomianny, Christian | Morin, Jean-Charles | Thomas, Patrick | Kalamou, H. | Guérardel, Yann | Cloetens, Peter | Khalife, Jamal | Biot, Christophe

Edité par CCSD ; Royal Society of Chemistry -

International audience. We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.

Consulter en ligne

Suggestions

Du même auteur

Deciphering the resistance-counteracting functions of the antimalarial ferroquine in Plasmodium falciparum-infected erythrocytes

Archive ouverte | Dubar, Faustine | CCSD

International audience. he aminoquinoline chloroquine (CO) has been widely used for treating malaria since World War II. Resistance to CQ began to spread around 1957 and is now found in all malarious areas of the wo...

The antimalarial ferroquine: Role of the metal and intramolecular hydrogen bond in activity and resistance

Archive ouverte | Dubar, Faustine | CCSD

International audience. Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot fully explain the activity of ferr...

The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Archive ouverte | Dubar, Faustine | CCSD

International audience. Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected re...

Chargement des enrichissements...