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In vitro model for evaluating drug transport across the blood-brain barrier

Archive ouverte | Cecchelli, Roméo | CCSD

International audience. The passage of substances across the blood-brain barrier (BBB) is regulated in the cerebral capillaries, which possess certain distinct different morphological and enzymatic properties compar...

Physiological pathway for low density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro

Archive ouverte | Candela, Pietra | CCSD

International audience. Although an immense knowledge has accumulated concerning regulation of cholesterol homeostasis in the body, this does not include the brain, where details are just emerging. Using an in vitro...

Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury

Archive ouverte | Descamps, Laurence | CCSD

International audience. Numerous infections of the central nervous system are characterized by altered blood-brain barrier (BBB) functions leading to brain damage. To study the mechanisms that cause BBB disruption i...

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