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Does interference between replication and transcription contribute to genomic instability in cancer cells?

Archive ouverte | Tuduri, S. | CCSD

International audience. We have recently reported that topoisomerase 1 (Top1) cooperates with ASF/SF2, a splicing factor of the SR family, to prevent unscheduled replication fork arrest and genomic instability in hu...

Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

Archive ouverte | Crabbé, Laure | CCSD

International audience

Topoisomerase 1 suppresses replication stress and genomic instability by preventing interference between replication and transcription.

Archive ouverte | Tuduri, Sandie | CCSD

International audience. Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian ...

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