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Characterization of the CtsR stress response regulon in Lactobacillus plantarum.

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Fiocco, Daniela | Capozzi, Vittorio | Collins, Michael, J. | Gallone, Anna | Hols, Pascal | Guzzo, Jean | Weidmann, Stephanie | Rieu, Aurélie | Msadek, Tarek | Spano, Giuseppe

Edité par CCSD ; American Society for Microbiology -

International audience. Lactobacillus plantarum ctsR was characterized. ctsR was found to be cotranscribed with clpC and induced in response to various abiotic stresses. ctsR deletion conferred a heat-sensitive phenotype with peculiar cell morphological features. The transcriptional pattern of putative CtsR regulon genes was examined in the Delta ctsR mutant. Direct CtsR-dependent regulation was demonstrated by DNA-binding assays using recombinant CtsR and the promoters of the ctsR-clpC operon and hsp1.

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