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Lgals6, a 2-million-year-old gene in mice: a case of positive darwinian selection and presence/absence polymorphism.

Archive ouverte | Houzelstein, Denis | CCSD

International audience. Duplications of genes are widely considered to be a driving force in the evolutionary process. The fate of such duplicated genes (paralogs) depends mainly on the early stages of their evoluti...

Expression Patterns Suggest that Despite Considerable Functional Redundancy, Galectin-4 and-6 Play Distinct Roles in Normal and Damaged Mouse Digestive Tract

Archive ouverte | Houzelstein, Denis | CCSD

Chantier qualité GA. International audience. The galectin-4 protein is mostly expressed in the digestive tract and is associated with lipid raft stabilization, protein apical trafficking, wound healing, and inflamma...

Hypermutability of genes in Homo sapiens due to the hosting of long mono-SSR.

Archive ouverte | Loire, Etienne | CCSD

International audience. Simple Sequence Repeats (SSRs) are very common short repeats in eukaryotic genomes. Long SSRs are considered "hypermutable" sequences since they exhibit a high rate of expansion and contracti...

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