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Hypoxia in cancer cell metabolism and pH regulation.

Archive ouverte | Brahimi-Horn, M Christiane | CCSD

At a molecular level, hypoxia induces the stabilization and activation of the alpha-subunit of an alpha/beta heterodimeric transcription factor, appropriately termed HIF (hypoxia-inducible factor). Hypoxia is encountered, in parti...

The hypoxia-inducible factor and tumor progression along the angiogenic pathway.

Archive ouverte | Brahimi-Horn, M Christiane | CCSD

International audience. The hypoxia-inducible factor (HIF) is a transcription factor that plays a key role in the response of cells to oxygen levels. HIF is a heterodimer of alpha- and beta-subunits where the alpha-...

Oxygen, a source of life and stress.

Archive ouverte | Brahimi-Horn, M Christiane | CCSD

Oxygen is an essential element in the survival of complex organisms, however the level of oxygen, low or high, can be a source of stress depending on the biological context. Low levels of oxygen in tissues (hypoxia) can be the con...

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